Interestingly, a recent study showed that pro-inflammatory cytokines such as IL-6 and TNF-α downregulated the expression of CYP27B1 in colon cancer cells133, suggesting that the pro-inflammatory tumor microenvironment could be a contributing factor for decreased CYP27B1 levels during tumor progression. The gene discussed is CYP27B1; the disease is malignant colon neoplasm.