AP2S1 and epilepsy: We have shown that miR-210 directly interacts with and downregulates 4E-BP1 through its 3′-UTR along with a number of other genes of interest to synaptic function, including GRINA, TMUB1, and AP2S1. GRINA is a subunit of the NMDA receptor complex, which is a critical target of regulation during synaptic plasticity and has been associated with epilepsy and dysregulation by long-term consolidation in fear conditioning [28,61,62].