MALAT-1 seems to exert its oncogenic function via regulating the Ras homolog gene family, member A (RhoA)/Rho-Kinase (ROCK)-pathway, as downregulation of MALAT-1 reduces protein levels of RhoA, ROCK1 and 2 in osteosarcoma cell lines U2OS and HOS. This evidence concerns the gene MALAT1 and osteosarcoma.