Long non-coding RNA Forkhead box protein C2 antisense 1 (FOXC2-AS1) is overexpressed both in human osteosarcoma tissues and cell-lines MG63 and KH-OS resistant to doxorubicin (DXR), another important chemotherapeutic agent used in osteosarcoma treatment [32]. The gene discussed is FOXC2; the disease is osteosarcoma.