Importantly, TRAF6 overexpression in mouse Hematopoietic Stem Cells/Hematopoietgic Progenitor Cells (HSCs/HPCs) resulted in several defects of the hematopoietic system, including neutropenia, dysplasia and elevated platelets: neutropenia and thrombocytosis seem to be related to increased IL-6 production [114]. Here, TRAF6 is linked to Decreased total neutrophil count.