The role of miR-146a in targeting Stat1 in human T cells is also supported by the study of systemic lupus erythematosus (SLE) patients: in the PBMCs of these patients, a decreased miR-146a expression was observed, responsible for the induction of type I IFN through Stat1 and IRF5 targeting [75]. This evidence concerns the gene IRF5 and systemic lupus erythematosus.