Critically, the observed features of this subtype were independent of tumor size, with no significant difference between the highly branched “PBRM1 → SETD2” (mean tumor size, 105 mm) (Table S1) and the more monoclonal “multiple clonal driver” subtype (mean tumor size, 107 mm) (Table S1). The gene discussed is PBRM1; the disease is neoplasm.