The molecular landscape of ccRCC was elucidated by a number of next-generation sequencing studies (Cancer Genome Atlas Research Network, 2013, Dalgliesh et al., 2010, Sato et al., 2013, Scelo et al., 2014, Varela et al., 2011) that revealed frequent inactivation of the VHL tumor suppressor gene, alterations in the SWI/SNF complex (Varela et al., 2011), histone-modifying genes (Dalgliesh et al., 2010), and the PI3K/AKT/mTOR pathway (Cancer Genome Atlas Research Network, 2013, Sato et al., 2013, Scelo et al., 2014). Here, PIK3CA is linked to nonpapillary renal cell carcinoma.