Further studies have demonstrated that increased level of p‐H3Ser10 in tumor tissues is not due to changes in cell cycle but rather an interphase‐associated phenomenon, and p38‐MAPK/MSK1‐regulated increase of p‐H3Ser10 in GC is predictive of a more aggressive phenotype; this also could help defining the true negative margin of surgical resection.24 However, relatively few studies have investigated the role of H. pylori infection in these processes. This evidence concerns the gene RPS6KA5 and gastric cancer.