For example, hyperactivation of the receptor tyrosine kinase and RAS signaling pathways is a prominent feature of hypodiploid ALL and these cells demonstrate sensitivity to phosphoinositide 3-kinase (PI3K), but not mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibition in vitro [14]. This evidence concerns the gene WNK2 and acute lymphoblastic leukemia.