STAT6 and acute lymphoblastic leukemia: We show that the mechanism of this drug combination involves downregulation of signal transducer and activator of transcription 6 (STAT6) and PDGF-associated protein 1 (PDAP1), which appear to function in a predictedSTAT6–ERK–NF-κB regulatory network that may be implicated in apoptosis resistance in childhood ALL.