Resistant hypertension is defined as a blood pressure that is uncontrolled despite treatment with at least three blood pressure-lowering drugs, including a diuretic, usually also including an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) and a calcium channel blocker (CCB), and after exclusion of treatable secondary causes of hypertension.1 The gene discussed is ACE; the disease is hypertensive disorder.