Zona glomerulosa-like aldosterone-producing adenomas, unlike the classical Conn's adenoma, are more common in men than in women, are often small, and are more likely to present as resistant hypertension than a CT finding.25, 26, 27, 28 Our post-hoc finding of sex difference in the aldosterone–renin association is therefore notable in this context. This evidence concerns the gene REN and Hypertension resistant to conventional therapy.