Recent studies have shown that EMT, in which the cell‐cell junction is lost and cells lose the epithelial phenotype and acquire mesenchymal features, is a critical step in the process of cancer metastasis.42 Additionally, EMT plays a crucial role in VM formation.11 In our study, we tested whether EMT participates in the inhibition of VM formation by TP53INP1. Here, TP53INP1 is linked to cancer.