HIF1A and cancer: Vasculogenic mimicry (VM), a newly discovered blood supply model, is a vessel structure made of cancer cells and lacking endothelial cells.4 A hypoxic microenvironment not only leads to VM formation but also accelerates tumour metastasis, increasing the risk of resistance to chemotherapy in breast cancer.5, 6 The expression of hypoxia‐inducible factor‐1α (HIF‐1α) has been reported to be associated with VM in many cancers types, including liver cancer,7 ovarian cancer,8 colorectal cancer9 and melanoma.10 These observations suggest a new idea for inhibiting VM formation in hypoxia.