Epithelial‐mesenchymal transition (EMT) has also been confirmed to be associated with breast cancer cell invasion and is a key step for VM formation.11 Research has shown that HIF‐1α can influence EMT‐related gene expression, resulting in a cell phenotype change.12 Furthermore, reactive oxygen species (ROS) accumulated in the mitochondria could activate the EMT transcription factor Snail to promote cancer progression and participate in the regulation of HIF‐1α transcriptional activity.13 We speculated that hypoxia‐inducible EMT may be indispensable in VM formation in breast cancer. The gene discussed is HIF1A; the disease is breast carcinoma.