TP53INP1 and cancer: ROS can promote cancer progression and metastasis by regulating signalling pathways and intracellular metabolism in response to hypoxia.43, 44 EMT is induced through the activation of many transcription factors, such as Snail, MAPK and PI3K.43, 45, 46 We found high ROS levels in TP53INP1‐deficient cell lines.