SPARC and brain neoplasm: Liu et al found that TP53INP1 decreases liver cancer cell migration and invasion by inhibiting EMT.25 The down‐regulation of TP53INP1 promotes the metastasis of hepatocellular carcinoma through the p73‐mediated ERK signalling pathway.34 TP53INP1 can decrease cell migration by regulating SPARC expression in pancreatic cancer.24 TP53INP1 expression is decreased in metastatic brain tumours from the lung.35 In this study, our data confirmed that the role of TP53INP1 was negatively associated with VM in breast cancer.