Vasculogenic mimicry plays an important role in cancer progression.38, 39 VM can provide a blood supply for a malignant tumour, and it also provides a route for tumour cells to escape the primary lesion.4 Several molecular mechanisms and signal transduction pathways participate in VM formation.5, 6, 40 In vitro, we found that TP53INP1 knock‐down was associated with the formation of channel‐like structures in breast cancer cells. This evidence concerns the gene TP53INP1 and breast cancer.