Previous studies have showed that HCW is effective on decreasing inflammatory responses and inhibiting lipid peroxidation in CCl4‐treated mice.6, 7, 8 On the basis of these researches, our present study is designed to further investigate the hepatoprotective activity of HCW and the effect on modulating NF‐κB and TGF‐β1/Smad signalling pathways in CCl4‐induced hepatic fibrosis in rats. Here, NFKB1 is linked to Hepatic fibrosis.