RELN and Hirschsprung disease: These 6 genes functionally connected to each other via co‐expression, co‐localization and genetic interactions, and in particular NRSN1, RELN and GABRG2 were predicted to be involved in the processes of neuron projection, neuron‐neuron synaptic transmission and neuron part, further supporting all might contribute to the development of HSCR as HSCR is essentially caused by the defects in the enteric nervous system.