Neurensin 1 (NRSN1) is a neuron‐specific protein comprising one microtubule‐binding domain and several membrane domains, and it is particularly abundant in neuronal processes, such as the process of neurite extension.35 NRSN1, as a key regulator, may function in neuronal organelle transport and in the conduction of nerve signals, therefore contributing to axonal regeneration and development.36 In addition, the expression of NRSN1 has been proved to be down‐regulated in HSCR cases compared with normal controls,16 further supporting NRSN1 gene as a potential susceptibility gene to HSCR. The gene discussed is NRSN1; the disease is Hirschsprung disease.