1999). So, further studies should focus on the interaction between TGFβ, Smad3, GR and possible glucocorticoid insensitivity in WI‐38 human lung fibroblast cell line to provide greater insights in asthma‐related fibroblast to myofibroblast transdifferentiation and glucocorticoid resistance. The gene discussed is SMAD3; the disease is asthma.