IGHE and neoplasm: This model was selected because it provides i) a species in which the native FcεR is expressed on effector cell populations similar to human cells, ii) an opportunity to study syngeneic tumours in highly vascularized lungs of immunocompetent animals, iii) a self‐replenishing supply of native effector cells and iv) a chance to evaluate antibody safety in the presence of antitumour IgE‐mediated responses in tumour‐bearing animals.11