We previously reported that TNFα‐expressing mature macrophage subsets infiltrated tumour lesions and that elevated levels of TNFα were detected in lungs of rMOv18 IgE‐treated rats compared with controls.11 Here, we also observed significantly elevated circulating TNFα in IgE‐treated compared with PBS‐treated rats (P = .0044) (Figure 6A‐B).11 Previously, we found elevated macrophage chemoattractant protein‐1 (MCP‐1) in the lung environment of IgE‐treated animals potentiated by local upregulation of TNFα following IgE cross‐linking on tumour‐associated macrophages. The gene discussed is IGHE; the disease is neoplasm.