IGHE and neoplasm: This may be because IgE Fc‐mediated cross‐linking on tumour‐associated macrophages can trigger elevated TNFα, stimulating local tumour cells to produce MCP‐1 in the tumour, and not systemically.11 It is possible that tissue‐resident mast cells may also contribute to IgE‐mediated enhanced TNFα expression, and this requires further investigation.27 These suggest principally local induction of tumour‐associated immune mediator release, immune cell activation and recruitment by IgE immunotherapy.