Expression of the two predictive markers Her2 and ERβ was analyzed in 84 cases of CIS and normal urothelium from the same specimen and was significantly lower in normal urothelium than in CIS (p < 0.001) (median Her2 Dako score 1, median ERβ Remmele score 6) (Online Resource 3). Here, ERBB2 is linked to in situ carcinoma.