Here we examined the role of renal Hhip expression in murine models of diabetes mellitus—T1DM (in Akita mice22,23 and in low-dose streptozotocin (STZ) (LDSTZ)-induced diabetic heterozygous Hhip (Hhip+/−) mice24,25) and T2DM (db/db mice)24,26,27. Here, HHIP is linked to type 2 diabetes mellitus.