Steatosis also induced a downregulation of several phase II XMEs involved in B[a]P detoxification including glutathione-S-transferases (GSTs), sulfotransferases (SULTs) and UDP-glucuronosyl transferases (UGTs), as well as a downregulation of XMEs involved in ethanol metabolism such as alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs). The gene discussed is HPGDS; the disease is steatosis.