AICDA and diffuse large B-cell lymphoma: Somatic mutations in CREs interacting with PAX5 promoters showed both canonical AID (C > T/G in WRCY motifs with R = purine, Y = pyrimidine) and non-canonical AID (A > C/G in WA motifs) [31] mutational signatures (Fig. 5), in agreement with PAX5 enhancers mutated by AID in mouse B-cells and diffuse large B-cell lymphoma [30].