It was a bit puzzling that these quiescent CD4 + T cells, which expressed the receptors necessary for HIV fusion (CD4 and CXCR4, or CCR5), were resistant to HIV infection; nonetheless, the level of reverse transcripts were several logs lower in resting compared with activated CD4 + T cells when viral intermediates were measured shortly after inoculation (<24 h) [27]. The gene discussed is CD4; the disease is HIV infectious disease.