To test whether the RCAS-TVA-CRISPR-Cas9 system was also suitable for generating inter-chromosomal translocations, we decided to model the MYB-QKI gene fusion, a recently identified putative driver of a subtype of pediatric low-grade gliomas (PLGG), known as angiocentric gliomas47. Here, QKI is linked to low grade glioma.