EDN1 and coronary artery disorder: In summary, our finding provides the first evidence that EDN1 tagSNP rs6458155 and the haplotype rs6458155C-rs4145451C are associated with the risk of CAD in the Chinese Han population, suggesting that EDN1 gene polymorphisms may play an important role in the pathogenesis of CAD, although further studies with larger sample size are needed to validate our results.