CDKN2A and acute lymphoblastic leukemia: Moreover, we conducted in vitro experiments to further test the influence of variants at rs3731249 on leukemogenesis, and found p14ARF encoded by CDKN2A gene with variant allele of rs3731249 loses its ability to suppress leukemic transformation compared with the wild-type p14ARF, indicating rs3731249 is a potential causal variant to ALL susceptibility [14].