The actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) has been found overexpressed in most types of human cancer tissues and cell lines such as lung cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, esophageal cancer, pancreatic cancer, ovarian cancer, cholangiocarcinoma, and nasopharyngeal carcinoma [9]. This evidence concerns the gene AFAP1 and hepatocellular carcinoma.