Although the search for genetic susceptibility factors related to allergic diseases is a promising field, gene variations related to FcεRI as potential risk factors for allergic diseases have not been comprehensively analyzed, and the results available are in some cases contradictory, some studies showed the variant of Glu237Gly of FcεRIβ gene showed association with atopic diseases and the variant is also associated with very high total serum IgE levels [12–19], but others were showed no association with atopic asthma [20–22]. The gene discussed is IGHE; the disease is allergic disease.