TARDBP and amyotrophic lateral sclerosis: In ∼97% of ALS cases, cytoplasmic aggregates of TDP-43, a RBP with a prion-like domain (PrLD), are found in degenerating motor neurons (Guo and Shorter, 2017; Johnson et al., 2009; Ling et al., 2013; Neumann et al., 2006).