SNCA and Parkinson disease: The prominent protein associated with PD and DLB is α-synuclein (αSyn; encoded by SNCA), which is intrinsically disordered and forms amyloid inclusions called Lewy bodies (LB) (Bossy-Wetzel et al., 2004; Chu and Kordower, 2010; Giasson et al., 2003b; Spillantini et al., 1997).