Tau amyloid fibrils form intracellular neurofibrillary tangles (NFTs) in AD brains and are also found in frontotemporal dementia (FTD), Pick's disease, progressive supranuclear palsy, Parkinson's disease (PD) and dementia with Lewy bodies (DLB) (Giasson et al., 2003b; Lee et al., 1991). This evidence concerns the gene MAPT and Alzheimer disease.