In ALS cases without TDP-43 or SOD1 aggregates, cytoplasmic aggregates of FUS, another RBP with a PrLD, are found in degenerating neurons (Harrison and Shorter, 2017; Ling et al., 2013; March et al., 2016; Sun et al., 2011). Here, TARDBP is linked to amyotrophic lateral sclerosis.