Thus, introduction of synthetic PrP amyloids into mice induces prion disease (Choi et al., 2016; Colby et al., 2009; Legname et al., 2004, 2006; Wang et al., 2010), whereas αSyn fibrils induce a PD-like disease (Luk et al., 2012). Here, PRNP is linked to prion disease.