Indeed, Wrch-1 and Chp-1 have been shown to be important in focal adhesion turnover (Ory et al. 2007; Chuang et al. 2007; Aspenström et al. 2004), neural crest cell migration (Faure and Fort 2011; Notarnicola et al. 2008), and T-ALL cell migration (Bhavsar et al. 2013). Here, RHOU is linked to acute lymphoblastic leukemia.