These women also have an increased risk for early cancer onset, before screening recommendations apply, and for triple-negative tumors, that is tumors that test negative for estrogen, progesterone, and human epidermal growth factor  receptor 2 (HER2) and do not respond to hormonal therapy (eg, tamoxifen) or therapies that target HER2 receptors, (eg, herceptin) [2]. This evidence concerns the gene ERBB2 and cancer.