LRRK2 and Parkinson disease: Previous studies have indicated that mutations in several specific genes cause PD, including genes encoding alpha-synuclein (SNCA), leucine-rich repeat kinase 2 (LRRK2), glucocerebrosidase (GBA), parkin (PRKN), PTEN-induced putative kinase 1 (PINK1), parkinson disease protein 7 (PARK7), vacuolar protein sorting-associated protein 35 (VPS35), eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), dnaJ heat shock protein family (Hsp40) member C13 (DNAJC13) and coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) [6].