Using ROC curve analysis, we found that the critical serum level of MBL associated with the risk of RHD was 1383 ng/ml (AUC = 0.74, SE = 0.037, 95% CI = 0.67 to 0.82, p = < 0.0001, 73.3% sensitivity and 80% specificity). Here, MBL2 is linked to rheumatic heart disease.