SERPINB3 and neoplasm: Some studies have suggested that CYFRA 21-1 could be superior to SCC Ag in predicting response to therapy (chemotherapy or CRT) or survival in NSCLC and SCC of the oesophagus and the cervix [15, 20, 24], while another study has reported that both tumour markers could serve as useful markers to assess response to therapy and predict tumour recurrence in head and neck SCC [4].