FOXO1 and cancer: Overexpression of miR-186 also repressed the expression of tumor suppressors, including forkhead box O1 (FOXO1), Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2), and protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B) in endometrial [14], pancreatic [17], and bladder [20] cancer cells, respectively.