PTEN has the ability of suppressing various types of tumours and is a negative regulating factor of Wnt/β‐catenin.18 Hence, we assumed that miR‐130b's overexpression could activate Wnt/β‐catenin pathway via cutting down PTEN's protein level, which led to A549 cells' resistance to cisplatin. The gene discussed is PTEN; the disease is neoplasm.