The general cause of drug resistance in tumour cells is due to accumulation of changes in genes altered the genetic pathways, thus stimulating cancer cell evolution of phenotypes.19, 20 There have been limited effective solutions to solve the resistance problem in cancer treatment over the years.19, 21 Previous researches have demonstrated that PTEN is related with the drug resistance in various cancers.22 Our study gave evidence to the mechanistic connection of miR‐130b upregulation in cisplatin resistance in lung cancer. This evidence concerns the gene PTEN and neoplasm.