CD8A and cytomegalovirus infection: Whether such high numbers of CMV-specific CD8 T cells are important to assure control of CMV infection is rather unlikely, as CD8-deficient or transiently depleted mice are able to control lytic MCMV infection in peripheral organs, even though there is a moderate increase in virus titres, yet it is likely that there is a higher degree of latent viral loads [21, 46–50].