The genotypic frequencies of the rs776746 variant located in the CYP3A5 gene involved in the hypolipidemic susceptibility are similar between Tunisian and African populations (MKK, LWK, YRI) and significantly different from European (CEU) and Asian (CHD, CHB); (p<<0.05/5*10) (Table 2). This evidence concerns the gene CYP3A5 and coronary artery disorder.