JAG1 and malignant colon neoplasm: In line with these observations, the downregulation of JAGGED-1 induced the inhibition of cell proliferation, with reduced cyclin D1, cyclin E and c-Myc expression [411]; furthermore JAGGED-1 knockdown markedly reduced the growth of colon cancer cells in vivo in xenograft models, with marked downregulation of both proliferation and metastasis markers [414].