In the third study, De Sousa Melo and coworkers explored the roles of LGR5+ cells in murine models of colorectal cancer, showing that the ablation of LGR5+ cells in orthoptically transplanted tumors suppressed tumor growth only during cell ablation; in contrast, the elimination of LGR5+ cells in liver metastasis models led to the complete elimination of metastatic seeds [404]. Here, LGR5 is linked to colorectal cancer.