LGR5 and adenoma: Baker and coworkers have analyzed the spatial distribution of LGR5+ cells at the level of various adenomatous lesions showing that conventional adenomas display extensive expression of LGR5 and this expression is no longer restricted to the base of adenoma crypts; in contrast, in hyperplastic polyps and in serrated lesions, the basal localization of LGR5+ cells is retained, although their number is increased [66].