In tubular adenoma organoids, TGF-β activation induced apoptosis, consistent with its role in suppressing tumor growth; the expression of BRAFV600E mutant into tubular adenoma organoids, mimicking the serrated adenoma pathway, changed the response to TGF-β from apoptosis to the epithelial to mesenchymal transition [106]. Here, TGFB1 is linked to adenoma.