BRAF and colorectal cancer: According to these criteria, five subgroups were proposed: (i) the largest group including CIMP−, chromosomally unstable, MSS colorectal cancers (57% of cases); (ii) CIMP low, KRAS-mutated, MGMT-methylated, MSS/MSIlow (about 20% of cases); (iii) CIMPhigh, BRAF-mutated, MSI high (about 12% of cases); (iv) CIMP high, BRAF-mutated, chromosomally stable, MSS/MSI low (about 8% of cases); and (v) CIMP−, BRAF wt, chromosomally stable, MSI high (about 3% of cases) [95].