Nakayama et al. investigated the biologic properties of tumor organoids derived from the intestinal tumors of mice, which were APC-deleted and expressed two TP53-mutant (TP53R270H/R270H) alleles; these organoids were characterized by high tissue invasiveness and associated with a complex glandular structure, but unable to metastasize in vivo [284]. Here, APC is linked to intestinal neoplasm.