APC deletion caused adenoma formation and the combination with a TP53 mutation of TGFBR2-deletion-induced submucosal invasion; the addition of KRASG12D induced an EMT-like morphology and lymph node invasion; and APC deletion, in combination with KRASG12D and FBXW7 mutation, was insufficient to induce submucosal invasiveness, but induced an EMT-like morphology [298]. This evidence concerns the gene TP53 and adenoma.