As will be discussed in the section on tumor heterogeneity, the development of gene sequencing techniques allowed the evaluation of the mutational landscape of individual colon polyps, showing their consistent heterogeneity, and that even small polyps have multiple pathogenic mutations in crucial driver genes (APC, KRAS/NRAS, BRAF, FBXW7 and TP53). This evidence concerns the gene NRAS and neoplasm.