The majority of colorectal tumors follow a conventional pathway that is initiated by activating mutations of the WNT pathway; however, 10–15% of colorectal cancers are believed to initiate via activating mutations in the BRAF oncogene, which amplifies MAPK signaling and drives the serrated neoplastic pathway to colorectal cancer (Figure 3). This evidence concerns the gene BRAF and colorectal neoplasm.