The benefic effect induced by aspirin does not seem to be related only to its anti-inflammatory and direct anti-tumor effects, but also to the activation of T-cell-mediated anti-tumor immunity; in fact, Hamada and coworkers observed in the context of the Nursey’ Health Study and Health Professionals Follow-Up Study that the survival benefit associated with aspirin administration is stronger in colorectal cancers with a lower CD274 (PD-L1) expression [110]. The gene discussed is CD274; the disease is neoplasm.