A recent study reported a FCPIK3CA murine cancer model, based on the expression of a constitutive phosphatidyl-inositol-3 kinase (PI3K) in the intestinal epithelium: this constitutive PI3K activity resulted in tissue hyperplasia and the formation of invasive mucinous adenocarcinomas [46]. Here, PIK3CA is linked to mucinous adenocarcinoma.