The results of this interesting study showed that: (i) protein-truncating mutations occurred in 69.4% of these patients; (ii) LOH at APC was detected in 32.1% of colorectal cancers, mostly caused by chromosomal deletion; and (iii) 74.8% of cancers displayed either a LOH or at least one APC truncating mutation [53]. The gene discussed is APC; the disease is cancer.