Colon cancer stem cells were shown to express the CD44 and the epithelial adhesion molecule EpCAM; furthermore, in some colorectal cancers, cancer stem cells were found also to express CD166 and the positivity for this antigen, associated with CD44 and EpCAM positivity, could be used for further enrichment of colon cancer stem cells [374]. This evidence concerns the gene CD44 and colonic neoplasm.