The results of this study showed that the tumor expression of ALDH1, CD133 and SOX2 are nor correlated; elevated SOX2 expression is associated with a higher tumor grade and BRAFV600E mutation; high CD133 and high SOX2 expression are associated with reduced overall survival; and high expression of immune markers CD3 and FoxP3 is associated with a better overall survival [458]. The gene discussed is PROM1; the disease is neoplasm.