KRAS and adenoma: Their results showed that the presence of recurrent alterations in known cancer driver genes, such as APC, KRAS, FBXW7 and TCF7L2 and abnormalities in chromosomes 5, 7 and 13; 80% of adenomas displayed somatic alterations in WNT pathways; the adenomas displayed evidence of multiclonality similar to stage I carcinomas [219].