This conclusion was reinforced by a more recent study showing the existence in early-stage colon cancer stem cells of an incoherent feedforward loop, targeting both NOTCH and NUMB (an antagonist of NOTCH signaling causing its endocytosis and degradation) via miR-34a and favoring the asymmetric cell division of colon cancer stem cells [407]. The gene discussed is NUMB; the disease is malignant colon neoplasm.