APC and colon adenoma: APC is the gene most frequently mutated in conventional colon adenomas; four genes recurrently mutated in adenomas CTNNB1 (catenin-β1), KRTAP4-5 (keratin-associated protein 4–5), GOLGA8B (golgin A8 family member B) and TMPRSS13 (transmembrane protease, serine 13) had the oncogene pattern [222].