APC and colorectal carcinoma: About 10% of these 1058 partecipants carried one or more pathogenic germline mutations, including 3.1% with Lynch syndrome, 7% with non-LS gene mutations, including 2.2% with mutations in high-penetrance genes (APC; biallelic MUTYH), and 3.6% with moderate-penetrance CRC risk gene mutations (monoallelic MUTYH, APCI1307K, CHEK2) [80].