The role of p53 during intestinal tumorigenesis is complex and different at early stages, compared to late stages of tumor development; thus, in the initial stages p53 exerts its orthodox effects on DNA damage and intestinal epithelial cell survival, while during tumor progression p53 loss is responsible for increased intestinal permeability, inducing the formation of an NF-kB-dependent inflammatory microenvironment and the epithelial–mesenchymal transition [45]. The gene discussed is NFKB1; the disease is neoplasm.