Thus, recently, it a preventive approach aiming to prevent the development of resistance by treating colon cancer cells with EGFR inhibitors plus MEK inhibition was proposed: this combined treatment, evaluated in xenotransplantation models of colorectal cancer, showed that the combined treatment resulted in a more effective induction of apoptosis than single agents alone, and in a limitation of the emergence of resistant clones [152]. This evidence concerns the gene EGFR and colorectal cancer.