Recent studies have shown that virtually all (99%) CRCs developing in Lynch syndrome patients display MSI-H; the most mutated genes exhibiting microsatellite repeats are ACVR2A, TGFBR2, EGFR, BPMR2, E2F4, MSH3, BAX and TCF7L2 [147]. This evidence concerns the gene TGFBR2 and Lynch syndrome.