In fact, a recent study showed that LGR5+ intestinal stem cells express the tumor suppressor RNF43, a stem cell E3-ligase-inducing endocytosis of Wnt receptors: thus, this ligase reduces Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation [21]. This evidence concerns the gene LGR5 and neoplasm.