LS (also known as hereditary nonpolyposis colorectal cancer, HNPCC) is an autosomal, dominantly inherited syndrome caused by germline mutation in one of the mismatch repair genes, MLH1, MSH2, MSH6 and PMS2 or the EPCAM gene (Figure 3) [77]. This evidence concerns the gene EPCAM and hereditary nonpolyposis colon cancer.