The results of trials performed in 2419 colorectal cancer patients diagnosed between 1997 and 2008 were recently published, providing clear evidence that the administration of aspirin or any nonsteroidal anti-inflammatory after tumor diagnosis was associated with an improved overall survival among participants with KRAS wild-type tumors, but not among tumors with KRAS-mutant tumors [109]. This evidence concerns the gene KRAS and neoplasm.