Particularly, they showed that transgenic mice expressing constitutively active IkB kinase (IkkB) in intestinal epithelial cells developed intestinal tumors after a long period of latency; however, when these mice were crossed with mice with APC allelic loss, the resulting hybrid mice developed more β-catenin-positive early lesions and more colon tumors and reduced survival. This evidence concerns the gene APC and colonic neoplasm.