A total of 22 tumor-related genes were found to be mutated in these adenomas, the most frequently mutated being APC (10/12), KRAS (7/12), SMAD4 (3/12), AERBB4 (2/12), TCF7L2 (2/12), AMER1 (2/12), TP53 (2/12) [224]. Here, SMAD4 is linked to neoplasm.