This contact mutant has also been described to acquire GOF with clinical relevance, related to the transcription of noncanonical p53 target genes, namely MAP2K3 (involved in increased cell proliferation), MVK and FDFT1 (involved in lipid metabolism with tumor progression), CENP-A (related to chromosomal instability), and the more recently reported ENTPD5 (promoting cell proliferation and colonization) [8,18,30,31]. Here, TP53 is linked to neoplasm.