TGFB1 and neoplasm: Nanovesicles released by tumor cells express immunosuppressive molecules such as Fas Ligand (FasL) [63,64], Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL), Programmed death-ligand 1 (PD-L1), and Interleukin 10 (IL-10), as well as microenvironment conditioning factors, e.g., transforming growth factor β (TGF-β1), prostaglandin E2 (PGE2), and ectoenzymes engaged in the adenosine pathway (CD39 and CD73) [16,65,66,67].