Activation of RXR signalling leads to GADD45 signalling, which hasanti-proliferative properties.60,61 GADD45 signalling wasenriched at the onset of the hypertension (9 weeks) in the SHR as well as ananti-proliferative and anti-migratory effect of miRNAs: mir-744-5p, mir-29b-3p,mir-296-5p, mir-149-3p and mir-4707-3p. This evidence concerns the gene GADD45A and hypertensive disorder.