At the development of hypertension, two additional pathways were affected –GADD45 signalling and axon guidance signalling but Graft-vs-Host diseasesignalling, OX40 signalling and dendritic cell maturation signalling,remained unchanged (p = 0.1, p = 0.06 andp = 0.2, respectively). The gene discussed is TNFRSF4; the disease is hypertensive disorder.