GADD45A and Hypertension: Of the pathways involved in maturation of the blood vesselsin hypertension, six were specific to pre-hypertensive, 5-week-old SHR.During the development of hypertension (9-week-old SHR) only one pathway wasspecific to that stage (GADD45 pathway) while 12 pathways were specific to13-week-old SHR, a time when hypertension is established.