BCL2 and cancer: TQ induced apoptosis involves changes in mitochondrial membrane potential, activation of caspases and PARP cleavage [88], increase in the Bax/Bcl-2 ratio via downregulating Bcl-2 and upregulating Bax level [88], raise in level of cytochrome c and caspase-3, along with suppressed expression of Bcl-xL and survivin [74], degradation of alpha and beta tubulin, and increase in p73 expression leading to apoptosis in cancer cells [87].