We hypothesize that TQ might help overcome those immunosuppressive mechanisms [160–162] in GBM immunotherapy and therefore further investigations are required for the potential role of TQ in different immunotherapeutic modules including the potential synergistic role of TQ on the therapeutic efficacy of immune checkpoints (CTLA-4 and PD-1) blockers for the treatment of GBM (Figure 3). Here, CTLA4 is linked to glioblastoma.