When crossed with K14-Cre (Derksen et al., 2006) or Wap-Cre (Derksen et al., 2011) to conditionally knockout Cdh1 and p53 in mammary basal epithelial cells or epithelial cells, respectively, the resulting K14-Cre; Cdh1 f/f; Trp53 f/+ developed mammary and skin tumors with T50 of 71 weeks. This evidence concerns the gene KRT14 and skin neoplasm.