CDH1 and breast cancer: In contrast, the Wap promoter versions of similar crosses, Wap-Cre; Cdh1 f/f; Trp53 f/+, formed mammary tumor with T50 of 83 weeks (calculated from Kaplan-Meier tumor free survival) which was much longer latency than Wap-Cre; Cdh1 f/f; Trp53 f/f (T50 = 28 weeks), Wap-Cre; Cdh1 f/+; Trp53 f/f (T50 = 45 weeks), and Wap-Cre; Cdh1+/+; Trp53 f/f (T50 = 42 weeks) (Derksen et al., 2011).