After these initial changes the haemangiomas continued to improve until they were nearly flat, with residual skin telengectasias.5 The therapeutic effect of propranolol on infantile capillary hemangiomas is because of vasoconstriction leading to immediate improvement and decreased expression of VEGF and bFGF genes through the down-regulation of the RAF–mitogen-activated protein kinase pathway18 and the triggering of apoptosis of capillary endothelial cells19 leading to long term improvement. This evidence concerns the gene FGF2 and capillary hemangioma.