Although serum CK18, MMP-9, and TIMP1 preop measurements in patients scheduled for curative surgery due to gastric adenocarcinoma did not help to gain any idea of tumor resectability, we concluded that our study had valuable results in significantly predicting the N3 stage, and we believe that studies should be conducted with a larger number of patient groups in this area. This evidence concerns the gene TIMP1 and gastric adenocarcinoma.