Early administration of hyperoxaluric mice with the anti-TGFβ (oxalate + anti-TGFβ) or control IgG1 antibody (oxalate + IgG1) significantly reduced intrarenal CaOx crystal deposits compared to untreated mice with nephrocalcinosis (oxalate only) after 14 days (Figure 2A). The gene discussed is TGFB1; the disease is nephrocalcinosis.