BECN1 and myocardial ischemia: In this study, we confirmed that autophagy was initiated with a significant increase in autophagic vacuoles, enhancement of LC3-II/LC3-I ratio and Beclin 1 level and decrease in p62 level in the myocardial ischemia injured rats, LLC could counteract the autophagy process as evidence by a decreased autophagic vacuoles, LC3-II/LC3-I ratio and Beclin 1 level as well as an elevation of p62 level.