RHO and retinal disorder: Thirdly, recent studies in which crb was mutagenized at conserved residues located in the extracellular domain that are associated with human retinopathies, have revealed a complex pattern of trafficking for Crb, and how it might in turn influence Rhodopsin trafficking, including endocytosis (Lin et al., 2015; Pellikka and Tepass, 2017).