This is interesting because mutations in one of the crb human orthologs, CBR1, lead to retinitis pigmentosa (RP12) and Leber Congenital Amaurosis (LCA), which are inherited retinopathies characterized by photoreceptor degeneration and blindness (Richard et al., 2006; den Hollander et al., 2008). The gene discussed is CRB1; the disease is Leber congenital amaurosis.