This is interesting because mutations in one of the crb human orthologs, CBR1, lead to retinitis pigmentosa (RP12) and Leber Congenital Amaurosis (LCA), which are inherited retinopathies characterized by photoreceptor degeneration and blindness (Richard et al., 2006; den Hollander et al., 2008). This evidence concerns the gene CBR1 and Leber congenital amaurosis.