Involvement of CDK5 in ανβ3-mediated cell migration is further supported by the observation that in C6 glioma cells, that do not express ανβ32, pharmacological inhibition of CDK5 by roscovitine has no effect in the inhibitory effect of PTN in the migration of these cells (Supplementary Fig. S2d). This evidence concerns the gene CDK5 and glioma.