Our results showed that parents with heterozygous mutations in NKX2-1, PAX8 and FOXE1 were euthyroid, suggesting that CH caused by mutations of PAX8, NKX2-1 and FOXE1 is not inherited in the classic autosomal dominant manner, which is inconsistent with previous reports (45). This evidence concerns the gene PAX8 and cyclic hematopoiesis.