RPGRIP1L and ciliopathy: Since the phenotype of Rpgrip1l−/− mouse embryos is more severe than the phenotype of many other mouse mutants suffering from the loss of a TZ protein (Czarnecki & Shah, 2012; Norris & Grimes, 2012) and since mutations in RPGRIP1L lead to a far broader spectrum of human ciliopathies than mutations in most other TZ protein‐encoding genes (Zaghloul & Katsanis, 2010), one may expect a high ranked position of Rpgrip1l in the vertebrate TZ assembly hierarchy comparable to that in C. elegans.