Similar to Cep290−/− mouse embryos, mice having mutations in genes encoding components of the Mks/B9 module suffer from very severe ciliopathies (Reiter & Skarnes, 2006; Cook et al, 2009; Weatherbee et al, 2009; Cui et al, 2011; Garcia‐Gonzalo et al, 2011; Sang et al, 2011; Collin et al, 2012). The gene discussed is CEP290; the disease is ciliopathy.