It is difficult to interpret the continued use of albumin for volume expansion as a lack of knowledge of the evidence, since worse outcomes in the albumin-treated arm in SAFE-TBI may have been the consequence of a hypotonic carrier causing elevated ICP [30], and well-informed clinicians may have used albumin that was isotonic or corrected any accompanying hyponatremia. The gene discussed is ALB; the disease is Hyponatremia.