In a follow-up study, patients with larynx cancer were evaluated to determine whether γH2AX phosphorylation (pH2AX), a component of the histone octamer in nucleosomes which is phosphorylated upon DNA damage, alone or in combination with the membrane protein MAP17 could be used as a prognostic biomarker [135]. The gene discussed is PDZK1IP1; the disease is larynx cancer.