The y-linked autoimmune accelerator (yaa) allele is the most potent disease allele on the Y chromosome detected in BXSB mouse strain involved in the pathogenesis of lupus nephritis; however, yaa could produce disease only when combined with other autoimmune promoting genes [35, 36].TLR7-driven type I interferon secretion can also promote hematopoietic abnormalities [37]. Here, TLR7 is linked to lupus nephritis.